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Bhaskar Gurram, Miao Li, Jiangli Fan, Jingyun Wang, Xiaojun Peng
《化学科学与工程前沿(英文)》 2020年 第14卷 第1期 页码 41-52 doi: 10.1007/s11705-019-1796-1
关键词: cyclooxygenase-2 nile blue CCB Golgi apparatus NIR imaging
Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 90-95 doi: 10.1007/s11684-010-0021-x
关键词: cyclooxygenase-2 gene single nucleotide polymorphisms susceptibility primary hepatocellular carcinoma hepatitis B virus infection
Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG
《医学前沿(英文)》 2009年 第3卷 第2期 页码 164-170 doi: 10.1007/s11684-009-0038-1
关键词: epithelial-mesenchymal transition vascular endothelial cell growth factor matrix metalloproteinase-9 cyclooxygenase-2 higher microvascular density breast cancer
null
《医学前沿(英文)》 2015年 第9卷 第4期 页码 496-507 doi: 10.1007/s11684-015-0414-y
Perioperative parecoxib administration reduces postoperative pain, opioid consumption, and adverse events in adult patients. However, the efficacy and safety of parecoxib in children remain unclear. This meta-analysis included related published studies to address this concern. Eight databases in the literature until February 2015 were systematically explored to identify randomized controlled trials (RCTs) comparing perioperative parecoxib administration and placebo/standard treatments for acute postoperative pain in children. Primary outcomes were postoperative pain scores and adverse events. The Face, Legs, Activity, Crying, Consolability scale was used to score pain in children younger than 6 years, whereas the Visual Analog Scale was used in children older than 6 years. Secondary outcomes were sedation scores (measured using the Ramsay scale), agitation scores (measured using the Sedation-Agitation Scale), and opioid consumption. The methodological quality of RCTs was independently assessed in accordance with the “Risk of bias” of Cochrane Collaboration. Data were analyzed using Review Manager 5.2. Twelve RCTs involving 994 patients met the inclusion criteria. Compared with children who received placebo treatment, those who received parecoxib demonstrated lower early (2 h) and later (12 h) postoperative pain scores; lower incidence rates of postoperative nausea, vomiting, and agitation; higher early (1 h) postoperative sedation scores; and lower agitation scores. Similarly, children who received parecoxib had lower early (2 h) and later (12 h) postoperative pain scores, lower incidence rates of postoperative nausea and vomiting, and lower early (1 h) postoperative sedation scores compared with those who received standard treatments; however, these children showed no significant difference in agitation scores. Unfortunately, data on the effect of parecoxib on opioid consumption were insufficient. Overall, these results suggested that perioperative parecoxib administration was associated with less acute postoperative pain and fewer adverse events compared with placebo or standard treatments. Parecoxib administration also resulted in less emergence agitation compared with placebo treatment and less excessive sedation concern compared with standard treatments. However, the long-term effects, effects on opioid consumption, and patient satisfaction of parecoxib administration warrant further investigation.
关键词: NSAID cyclooxygenase 2 inhibitor child pain postoperative opioid placebo
Association of gene variants with juvenile amyotrophic lateral sclerosis
《医学前沿(英文)》 doi: 10.1007/s11684-023-1005-y
关键词: TRMT2B amyotrophic lateral sclerosis mitochondrial complex I tRNA methylation reactive oxygen species
Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia
Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 101-105 doi: 10.1007/s11684-010-0017-6
关键词: schizophrenia cytosolic phospholipase A2 ligase detection reaction polymorphism
Zhao DING, Zhishui CHEN, Xilin CHEN, Ming CAI, Hui GUO, Nianqiao GONG
《医学前沿(英文)》 2009年 第3卷 第2期 页码 204-210 doi: 10.1007/s11684-009-0039-0
关键词: anti-ERK2 renal transplantation epithelial mesenchymal transition chronic allograft nephropathy
a novel K+ transporter gene in cotton
Yiru WANG, Juan XU, Mingcai ZHANG, Xiaoli TIAN, Zhaohu LI
《农业科学与工程前沿(英文)》 2018年 第5卷 第2期 页码 226-235 doi: 10.15302/J-FASE-2017170
夏家辉
《中国工程科学》 2000年 第2卷 第11期 页码 1-11
关键词: 遗传病家系 基因定位和克隆 基因家族-候选疾病基因克隆 基因组扫描 基因功能研究
null
《医学前沿(英文)》 2017年 第11卷 第1期 页码 120-128 doi: 10.1007/s11684-017-0501-3
Norepinephrine transporter (NET) transfection leads to significant uptake of iodine-131-labeled metaiodobenzylguanidine (131I-MIBG) in non-neuroendocrine tumors. However, the use of 131I-MIBG is limited by its short retention time in target cells. To prolong the retention of 131I-MIBG in target cells, we infected hepatocarcinoma (HepG2) cells with Lentivirus-encoding human NET and vesicular monoamine transporter 2 (VMAT2) genes to obtain NET-expressing, NET-VMAT2-coexpressing, and negative-control cell lines. We evaluated the uptake and efflux of 131I-MIBG both in vitro and in vivo in mice bearing transfected tumors. NET-expressing and NET-VMAT2-coexpressing cells respectively showed 2.24 and 2.22 times higher 131I-MIBG uptake than controls. Two hours after removal of 131I-MIBG-containing medium, 25.4% efflux was observed in NET-VMAT2-coexpressing cells and 38.6% in NET-expressing cells. In vivo experiments were performed in nude mice bearing transfected tumors; results revealed that NET-VMAT2-coexpressing tumors had longer 131I-MIBG retention time than NET-expressing tumors. Meanwhile, NET-VMAT2-coexpressing and NET-expressing tumors displayed 0.54% and 0.19%, respectively, of the injected dose per gram of tissue 24 h after 131I-MIBG administration. Cotransfection of HepG2 cells with NET and VMAT2resulted in increased 131I-MIBG uptake and retention. However, the degree of increase was insufficient to be therapeutically effective in target cells.
关键词: norepinephrine transporter vesicular monoamine transporter 2 -MIBG gene therapy lentivirus vector
RR1 and RR2 gene deletion affects the immunogenicity of a live attenuated pseudorabies
Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN
《农业科学与工程前沿(英文)》 2016年 第3卷 第1期 页码 81-86 doi: 10.15302/J-FASE-2016088
关键词: pseudorabies virus RR1 and RR2 ribonucleotide reductase vaccine candidate
Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast
Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen
《医学前沿(英文)》 2021年 第15卷 第4期 页码 621-628 doi: 10.1007/s11684-020-0738-0
关键词: early breast cancer 21-gene assay recurrence score prognosis
Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing
Yu Cao, Xiaoxuan Liu, Ling Peng
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 663-675 doi: 10.1007/s11705-017-1623-5
关键词: gene therapy RNAi therapeutics dendrimer nanovectors gene silencing
The antibiotic resistome: gene flow in environments, animals and human beings
null
《医学前沿(英文)》 2017年 第11卷 第2期 页码 161-168 doi: 10.1007/s11684-017-0531-x
The antibiotic resistance is natural in bacteria and predates the human use of antibiotics. Numerous antibiotic resistance genes (ARGs) have been discovered to confer resistance to a wide range of antibiotics. The ARGs in natural environments are highly integrated and tightly regulated in specific bacterial metabolic networks. However, the antibiotic selection pressure conferred by the use of antibiotics in both human medicine and agriculture practice leads to a significant increase of antibiotic resistance and a steady accumulation of ARGs in bacteria. In this review, we summarized, with an emphasis on an ecological point of view, the important research progress regarding the collective ARGs (antibiotic resistome) in bacterial communities of natural environments, human and animals, i.e., in the one health settings. We propose that the resistance gene flow in nature is “from the natural environments” and “to the natural environments”; human and animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene “circulation.”
Reflections on the system of evaluation of gene-edited livestock
Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI
《农业科学与工程前沿(英文)》 2020年 第7卷 第2期 页码 211-217 doi: 10.15302/J-FASE-2019303
The rapid development of biotechnology has provided a greater understanding of the biological functions of major candidate genes that have important functions regarding economic traits, and new materials for livestock breeding have been obtained through gene editing (GE) and embryo manipulation with the purpose of improving quality and output and reducing the costs and risk of disease. Public concerns, particularly over safety risks and production performance, must be addressed. Evaluation is the most important component of the regulation of gene-edited livestock and is a crucial guarantee of public safety before the marketing of gene-edited animal products. Here, the system of evaluation of gene-edited livestock is discussed in terms of public safety and production performance. The search for safe and ethical applications in the GE of livestock, a case-by-case evaluation strategy, and classification and simplification are used in order to promote a more efficient, objective, comprehensive and operable evaluation system.
标题 作者 时间 类型 操作
Near-infrared fluorescent probe for fast track of cyclooxygenase-2 in Golgi apparatus in cancer cells
Bhaskar Gurram, Miao Li, Jiangli Fan, Jingyun Wang, Xiaojun Peng
期刊论文
Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control
Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,
期刊论文
metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2
Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG
期刊论文
Efficacy and safety of perioperative parecoxib for acute postoperative pain treatment in children: a meta-analysis
null
期刊论文
Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia
Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,
期刊论文
Adenovirus-mediated antisense ERK2 gene therapy ameliorates chronic allograft nephropathy in a rat model
Zhao DING, Zhishui CHEN, Xilin CHEN, Ming CAI, Hui GUO, Nianqiao GONG
期刊论文
a novel K+ transporter gene in cotton
Yiru WANG, Juan XU, Mingcai ZHANG, Xiaoli TIAN, Zhaohu LI
期刊论文
Cotransfecting norepinephrine transporter and vesicular monoamine transporter 2 genes for increased retention
null
期刊论文
RR1 and RR2 gene deletion affects the immunogenicity of a live attenuated pseudorabies
Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN
期刊论文
Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast
Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen
期刊论文
Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing
Yu Cao, Xiaoxuan Liu, Ling Peng
期刊论文